Fibroids
Aetiology (Cause) of Fibroids
Genetic
 Intrinsic abnormalities of myometrium (uterine smooth muscle)
Increased Estrogen receptors in myometrium
Hormones
Act as 'promotors'
The role of family history
First degree relatives with myoma have 2.5 times increased risk of
developing myomas
The risks contributing to fibroid change
Increase 21% with each 10kg of body mass
Incidence falls with exercise/high parity
No increased risk with women on the PILL
Increased growth with exposure to Depo Provera
Some types of HRT (eg Raloxofene) accelerate fibroid shrinkage, but only
in menopausal patients
Fibroids can present with
Pain (rarely, when degenerating)
Bleeding (uncommon, unless they are submucosal)
Bladder symptoms (frequency)
Fertility (submucosal fibroids only, have been associated with reduced
fertility - intramural and subserosal are NOT implicated
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